Challenges and opportunities in many-core computing,”

With increasing use of computers that employ many independent processing units, commercial and technical-scientific software, as well as general-purpose operating systems, will have to undergo fundamental changes. By John L. Manferdelli, Naga K. Govindaraju, and Chris Crall ABSTRACT | In this paper, we present some of the challenges and opportunities in software development based on the current hardware trends and the impact of massive parallelism on both the software and hardware industry. We indicate some of the approaches that can enable software development to effectively exploit the many-core architectures. Some of these include encapsulating domain-specific knowledge in reusable components, such as libraries, integrating concurrency with languages, and supporting explicit declarations to help compilers and operating system schedulers. Tighter interaction between software and underlying hardware is required to build scalable and portable applications with predictable performance and higher power-efficiency. Overall, many-core computing provides us opportunities to enable new application scenarios that support enhanced functionality and a richer experience for the user on commodity hardware

The National Early Warning Score and its subcomponents recorded within ±24 hours of emergency medical admission are poor predictors of hospital-acquired acute kidney injury

YesBackground: Hospital-acquired Acute Kidney Injury (H-AKI) is a common cause of avoidable morbidity and mortality. Aim: To determine if the patients’ vital signs data as defined by a National Early Warning Score (NEWS), can predict H-AKI following emergency admission to hospital. Methods: Analyses of emergency admissions to York hospital over 24-months with NEWS data. We report the area under the curve (AUC) for logistic regression models that used the index NEWS (model A0), plus age and sex (A1), plus subcomponents of NEWS (A2) and two-way interactions (A3). Likewise for maximum NEWS (models B0,B1,B2,B3). Results: 4.05% (1361/33608) of emergency admissions had H-AKI. Models using the index NEWS had the lower AUCs (0.59 to 0.68) than models using the maximum NEWS AUCs (0.75 to 0.77). The maximum NEWS model (B3) was more sensitivity than the index NEWS model (A0) (67.60% vs 19.84%) but identified twice as many cases as being at risk of H-AKI (9581 vs 4099) at a NEWS of 5. Conclusions: The index NEWS is a poor predictor of H-AKI. The maximum NEWS is a better predictor but seems unfeasible because it is only knowable in retrospect and is associated with a substantial increase in workload albeit with improved sensitivity.The Health Foundatio

Non-natives: 141 scientists object [Letter]

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